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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.7
4.7
504 Reviews
$50 and over
Seafood

Make a reservation

2 people
7:00 PM
Booked 9 times today
Experiences are available.
  • Good for special occasions
  • Good for business meals
  • Fancy
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Dining areas

Additional information

Experiences

  • Culinary Passport: Peru

    $90.00 - $135.00 per person

    Mar 22, 2025 only
    Join us at M Brothers on Saturday, March 22, 2025, for the next stop on our Culinary Passport Dinners series! Indulge in a 4-course tasting menu inspired by the vibrant and diverse flavors of Peru. From the zesty flavors to the heartwarming stews and unique Andean ingredients, this menu offers an elevated taste of Peruvian cuisine. This experience is priced at $90 per person, or enhance your meal with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on March 22nd. Don’t miss this unforgettable culinary adventure!
    Culinary Passport: Peru Photo

What 504 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.7
4.7 based on recent ratings
  • 4.7Food
  • 4.7Service
  • 4.6Ambience
  • 4.5Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Best Value

  • Jacksonville

    Innovative

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers an exceptional dining experience with "innovative, fresh, and well-presented" dishes. Guests praise the "outstanding service" and "delicious food" in a "beautiful setting." Popular items include the "best burger ever" and "phenomenal" house salads. Monthly themed dinners and "live music" create a delightful atmosphere, making it a "hidden gem" in Jacksonville.

504 Reviews
  1. Connie

    Tallahassee2 reviews

    5.0

    Dined 4 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Best waitress and food was exceptionally good! Recommend the bread plate as a starter!

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  2. Larry VIP

    Jacksonville16 reviews

    5.0

    Dined on March 1, 2025

    1. Overall 5
    2. Food 4
    3. Service 4
    4. Ambience 5
    Marie welcomed us and seated us promptly. Briana was informative and suggested items. Food and wine was outstanding and ample. Desert was shared to cap off a nice dinner. Valet parking was close by and appreciated.
    M Brothers at MayoResponded on March 3, 2025
    Thank you for the lovely review! We're so glad you had a great experience, from Marie's warm welcome to Briana's helpful suggestions. We hope to welcome you back soon for another outstanding dinner!

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  3. Robert

    Cleveland3 reviews

    4.0

    Dined on February 24, 2025

    1. Overall 4
    2. Food 5
    3. Service 5
    4. Ambience 4
    The food was great, our waitress was fabulous (very accommodating, went above and beyond the call of duty, and funny!), but the hostess was rude. Send the hostess to hospitality training so that she can understand what that word means. Despite her rudeness, I would go back when I have an appointment at Mayo.
    M Brothers at MayoResponded on March 3, 2025
    Thank you for your feedback! We're so glad you enjoyed the food and service, and we’ll address your comments about the hostess. We appreciate your understanding and look forward to welcoming you back soon! 😊

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  4. Carol VIP

    Jacksonville9 reviews

    5.0

    Dined on February 22, 2025

    1. Overall 5
    2. Food 4
    3. Service 5
    4. Ambience 4
    We had a great meal in the style of the country of Turkey. Everything was delicious.
    M Brothers at MayoResponded on March 3, 2025
    Thank you for the great review! We're so glad you enjoyed the Turkish-inspired meal. Hope to see you again soon for our next Passport Dinner, inspired by Peru on March 22nd!

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  5. Michael

    Jacksonville1 review

    5.0

    Dined on February 22, 2025

    1. Overall 5
    2. Food 5
    3. Service 4
    4. Ambience 5
    Another enjoyable evening with the ‘If it grows together’ parings chef has created. All courses from Turkey were wonderful, but the Smoky tomato sauce on the second course… he better make that a staple on the everyday menu or he is missing out on easy money. Always a great experience.

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  6. Clare VIP

    Jacksonville16 reviews

    5.0

    Dined on February 22, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Excellent wine dinner -- creative cuisine and perfect pairings.
    M Brothers at MayoResponded on March 3, 2025
    Thank you for the fantastic review! We're so glad you enjoyed the wine dinner and pairings. We hope to welcome you back for another amazing experience soon on March 22, inspired by Peru! 🍷🍽️

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  7. JP

    Jacksonville13 reviews

    4.0

    Dined on February 18, 2025

    1. Overall 4
    2. Food 4
    3. Service 4
    4. Ambience 4
    Excellent food, service and ambience. We always lunch at M Brothers when we visit the Mayo Clinic.
    M Brothers at MayoResponded on March 3, 2025
    Thank you for the wonderful review! We're so happy to be your go-to spot during your visits to Mayo Clinic. We look forward to seeing you again soon! 😊

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  8. Teri

    Jacksonville1 review

    5.0

    Dined on February 18, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    We enjoyed our delicious lunch and excellent service. Highly recommend!
    M Brothers at MayoResponded on February 21, 2025
    Thank you for the kind words! We're so glad you enjoyed your lunch and the service. We appreciate the recommendation and look forward to having you back soon!

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  9. Sean

    Jacksonville1 review

    1.0

    Dined on February 16, 2025

    1. Overall 1
    2. Food 2
    3. Service 1
    4. Ambience 3
    We decided to try M Brothers at Mayo, even though it's in a weird location, because we are fans of all Medure Brothers restaurants. Restaurant Medure is one of our favorite restaurants at the beaches and we were frequent guests at M Shack AB before it closed. Unfortunately, this was one of the worst fine dining experiences we've had in a long time. After we were seated, it was 10 minutes before our server, or anyone, came by. Our server rarely came to our table after that. We ordered a couple cocktails (which were OK) and we weren't in any hurry but she came so infrequently that at one point we asked her to please leave a pitcher of water so we could serve ourselves. After an appetizer of fish bites (which were pretty good) she took our utensils. While we were waiting for our utensils, the table next to us returned their entree because it had a long hair in it. Our main dish was delivered 15 minutes later and she hadn't come back and we still didn't have utensils. My main dish was a half rack of lamb and it was pretty good but nothing exceptional. My wife ordered the prime ribeye (rare) with twice baked potato. The steak was tough and full of gristle. The "twice baked potato" was half a potato with some toppings on top, not an actual twice baked potato. Worse yet, the potato was undercooked so it was still hard. My wife couldn't eat much of her entree, despite really trying. She rarely complains, but she was excited about the entree and was really disappointed. To their credit, we told them about the steak and potato and they sent it back to the chef. He agreed it wasn't to their level of quality and took it off our bill, but the poor service and bad entree made for an overall poor experience. We won't ever be back. It makes us appreciate our experiences at Restaurant Medure a little more.

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  10. Van

    Jacksonville7 reviews

    5.0

    Dined on February 15, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Nice place, recommend 10 out of 10 times. Service was excellent.
    M Brothers at MayoResponded on February 21, 2025
    Thank you for the glowing review! We're thrilled to hear you had a great experience. We truly appreciate your recommendation and look forward to having you back soon!

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FAQs

M Brothers at Mayo is rated 4.7 stars by 504 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a reservation

2 people
7:00 PM
Booked 9 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Phone number
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Privacy Policy
  • Terms of Use
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