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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.8
4.8
476 Reviews
$50 and over
Seafood

Make a reservation

2 people
7:00 PM
Booked 10 times today
Experiences are available.
  • Good for special occasions
  • Good for business meals
  • Fancy
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Phone number
    (904) 953-0409
  • Dress code
    Casual Dress

Experiences

  • Culinary Passport: Turkey

    $90.00 - $135.00 per person

    Feb 22, 2025 only
    Join us at M Brothers on Saturday, February 22, 2025, for the next stop on our Culinary Passport Dinners series! Savor a 4-course tasting menu inspired by the bold and vibrant flavors of Turkey. From the rich spices of Turkish cuisine to the fresh, savory ingredients that define it, this special menu will transport you to the heart of the Mediterranean. This experience is priced at $90 per person, or enhance your evening with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on February 22nd. Reserve your seat for this unforgettable culinary journey!
    Culinary Passport: Turkey Photo
  • Culinary Passport: Peru

    $90.00 - $135.00 per person

    Mar 22, 2025 only
    Join us at M Brothers on Saturday, March 22, 2025, for the next stop on our Culinary Passport Dinners series! Indulge in a 4-course tasting menu inspired by the vibrant and diverse flavors of Peru. From the zesty flavors to the heartwarming stews and unique Andean ingredients, this menu offers an elevated taste of Peruvian cuisine. This experience is priced at $90 per person, or enhance your meal with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on March 22nd. Don’t miss this unforgettable culinary adventure!
    Culinary Passport: Peru Photo

What 476 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.8
4.8 based on recent ratings
  • 4.8Food
  • 4.8Service
  • 4.6Ambience
  • 4.5Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Best Food

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Best Overall

  • Jacksonville

    Best Food

  • Jacksonville

    Best Service

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers "outstanding" dining with a "relaxing and beautiful" atmosphere, praised for its "exceptional" service and "delicious" food. The diverse menu includes favorites like Korean skewers, sea bass, and the Summer Truffle Tagliatelle. Monthly themed dinners are a "fantastic experience," making it a "hidden gem" at Mayo Clinic.

476 Reviews
  1. Shawn

    Jacksonville

    1 review

    5.0

    1 review

    Dined 1 day ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Everything from the service, the cocktails, and the food were extraordinary. The chef is blessed with talent, love and respect for food and it shows intensely. From start to finish our pallets were hit with bold and luscious flavors. We can’t wait to come back for more.

    Is this helpful?

  2. OpenTable Diner

    VIP

    Coastal Georgia

    9 reviews

    5.0

    9 reviews

    Dined 1 day ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great food and great service as always. MBros at Mayo never disappoints.

    Is this helpful?

  3. Nancy

    VIP

    Washington DC

    146 reviews

    4.0

    146 reviews

    Dined 2 days ago

    1. Overall 4
    2. Food 4
    3. Service 4
    4. Ambience 4
    M Bros is doing a great job. The menu is a bit different from most restaurants yet those who aren't looking for something different can still find their favorites too. Service is nice and attentive. The price is a bit higher than the run of the mill restaurant but the did quality and presentation make it worth it. It is still a bit strange coming to the hospital to go out to lunch or dinner but I've gotten past that as you can't tell that you're in the hospital building when you are inside the restaurant.

    Is this helpful?

  4. Hanna

    VIP

    Jacksonville

    9 reviews

    5.0

    9 reviews

    Dined on January 16, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    We can always count on M Brothers for a great experience! The food was delicious, the staff was awesome and the ambiance was exactly what we needed after a long day. Make sure to order apps and desserts, too. You won’t regret it!
    M Brothers at MayoResponded 4 days ago
    Thank you for your continued support! We’re so glad M Brothers hits the spot every time. Hope to see you again soon!

    1 person found this helpful

  5. Lorie

    Charlotte

    4 reviews

    5.0

    4 reviews

    Dined on January 13, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Love the addition of a relaxing atmosphere on a health system campus! A Health crisis will affect us all at some point! Love that we can decompress with good food and a crafted cocktail and never leave the campus!
    M Brothers at MayoResponded on January 14, 2025
    Thank you for sharing such a thoughtful review! We're so glad you appreciate the relaxing atmosphere and the opportunity to unwind with great food and drinks right on the health system campus. It’s our pleasure to offer that escape—hope to see you again soon! 🍸🍽️🌿

    1 person found this helpful

  6. James

    VIP

    Jacksonville

    3 reviews

    5.0

    3 reviews

    Dined on January 10, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Amazing food and service like normal! Thank you M Bros team!!!
    M Brothers at MayoResponded on January 14, 2025
    Thank you for the wonderful review! We're so happy to hear you had a memorable birthday celebration. Jordan, Dalvin, and the whole team are thrilled to have made the evening special for Hilary. Your kind words mean a lot to us, and we can’t wait to welcome you all back soon! 🎉🍾🌸

    1 person found this helpful

  7. alexis

    VIP

    Charleston

    70 reviews

    5.0

    70 reviews

    Dined on January 7, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Simply delicious. The food here is just wonderful. And so is the bar staff where we sat. The Korean skewers were my favorite. And the fried chicken bao. I miss the pork belly bites they used to do as well as the steak and gnocchi. Hope they bring those back. Fabulous find at Mayo!
    M Brothers at MayoResponded on January 8, 2025
    Thank you for the wonderful review! We're thrilled you enjoyed the food and the bar staff's hospitality. The Korean skewers and fried chicken bao are fan favorites! We'll pass along your love for the pork belly bites and steak & gnocchi. Hope to see you again soon at M Brothers at Mayo!

    1 person found this helpful

  8. Karen

    New Orleans

    6 reviews

    5.0

    6 reviews

    Dined on January 6, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    We had a lovely dinner and our waitress Destinee was terrific!
    M Brothers at MayoResponded on January 7, 2025
    Thank you for joining us! We're thrilled you had a lovely dinner and that Destinee took great care of you. We hope to see you again soon! 😊✨

    1 person found this helpful

  9. Ma

    Chicago

    70 reviews

    4.0

    70 reviews

    Dined on January 3, 2025

    1. Overall 4
    2. Food 4
    3. Service 5
    4. Ambience 3
    Nice alternative to the cafeteria at Mayo. Fresh fish was very good and husband enjoyed the shrimp etouffee. Service was efficient and friendly
    M Brothers at MayoResponded on January 6, 2025
    Thank you for dining with us! We're glad you enjoyed the fresh fish and shrimp étouffée, and we appreciate your kind words about our service. Hope to see you again soon!

    Is this helpful?

  10. Lisa

    Jacksonville

    39 reviews

    5.0

    39 reviews

    Dined on January 3, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great meal with excellent service. I always look forward to dining here.
    M Brothers at MayoResponded on January 6, 2025
    Thank you for your kind words! We're delighted you enjoyed your meal and service. We look forward to welcoming you back soon! 🍽️😊

    1 person found this helpful

FAQs

M Brothers at Mayo is rated 4.8 stars by 476 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a reservation

2 people
7:00 PM
Booked 10 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Neighborhood
    Jacksonville
  • Hours of operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Additional
    Bar/Lounge, Chef's Table, Non-Smoking, Private Room
  • Privacy Policy
  • Terms of Use
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