Best Cozy Restaurants in Medical Center

Price

$$
$$$
$$$$

Cuisine

AmericanItalianSteakhouseSeafoodFrenchMexican

Regions

San Antonio

Neighborhoods

Alamo HeightsDowntownFar West SideInner West SideLa CanteraLeon Springs

Top Rated

CharmingFancyGood for business mealsGood for groupsGood for special occasionsGreat for brunch

Dining Options

All dining options

Delivery only

Takeout only

Seating Options

BarCounterStandardHigh TopOutdoor

Accessibility

Gender-neutral restroomWheelchair access

55 restaurants available nearby

1. Clementine

4.9

Exceptional(561)

$$$$Price: Very Expensive

• Contemporary American • North Central

Booked 14 times today

At Clementine, we’re serving seasonal, innovative eats in a modern & lively atmosphere. Our team, led by John (2023 James Beard nominee for Best Chef: Texas) and Elise Russ, draws inspiration from diverse global flavors. Our ever-evolving menu guarantees fresh and exciting options, while our dishes like the White Mushroom Salad, Ricotta Cavatelli and Clementine Crunch Bar remain cherished favorites. Our beverage menu is small but mighty, carefully curated to include only the most delicious wines & beers from our absolute favorite producers expertly selected to elevate your dining experience. Want your own bottle? Our corkage fee is $35 per 750ml.Our Dining Room provides comfortable indoor seating, while the Kitchen Bar boasts an exciting vantage point overlooking our open kitchen, allowing you to witness the creation of each dish. For a change of scenery, our covered patio, is perfect for al fresco dining, complete with heaters and blankets to keep you cozy on those cool nights.

A photo of Luce Ristorante E Enoteca restaurant

2. Luce Ristorante E Enoteca

4.3

Awesome(1219)

$$$$Price: Moderate

• Italian • Medical Center

Booked 5 times today

Founded in 2006, Luce is a local favorite featuring many traditional dishes. Flavors which often bring our guests back to their best memories of Italian specialties.My goal for this restaurant to create a warm environment for all guests that is typical of a true Italian heritage. Our menu consists of many Buonincontri family recipes and recipes brought back from travel to Italy. Fresh fish, meats and produce expound throughout Luce's offerings and a focus on the finest ingredients are what make Luce special. House made Gnocchi, Italian rice balls and homemade Mozzarella are just a few examples our passion for the finest Italian food.The word Enoteca means wine library. The walls of the entire restaurant are covered with wine bottles as you would expect books to cover the walls of a library. Wine is a very important part of an experience at Luce, with over 125 choices from our wine list available to you.

A photo of Longtab Brewing Company restaurant

3. Longtab Brewing Company

new

3.0

Good(0)

$$$$Price: Moderate

• Brewery • Inner West Side

Longtab Brewing is a veteran owned brewery and restaurant serving local, scratch-made dishes, award winning craft beer made in house, as well as a selection of Texas wines and cider. Our restaurant serves an eclectic array of dishes inspired by a mix of Belgian, German, and local Texas fare!Enjoy our famous Pork Belly Nachos which are cut, seasoned, and smoked all in house, our best selling Cubano featuring beer-braised pork shoulder and pecan-smoked ham, or our German Bratwurst Plate featuring Texas bratwurst and German potato salad. Longtab's beer selection focuses on classic beer styles with a special focus on Belgian and German styles. We offer a casual atmosphere with elevated dining as well as outdoor seating. Our space is cozy and filled with US Army Special Forces artifacts and memorabilia.

A photo of Dean's Steak & Seafood restaurant

4. Dean's Steak & Seafood

4.6

Exceptional(305)

$$$$Price: Very Expensive

• Steak • Downtown

Booked 41 times today

Embrace the unique and step into the old school at Dean’s Steak & Seafood. Adapted into a historic 19th-century schoolhouse, this classic steakhouse and bar offers an elevated menu of prime steaks, A5 Japanese and Texas wagyu, and top-quality seafood. Simply put, this one-of-a-kind steakhouse is unlike anything else in the city.If you're looking for an elevated bar experience, visit The Study at Dean's. This intimate speakeasy bar is a cocktail aficionado’s haven, ideal for those who appreciate higher touch ingredients, presentation, and ambiance. Linger over high-end cocktails and small bites in a charming atmosphere with raised banquettes, brass details, and a dedicated outdoor patio shaded under century-old live oak trees - this is the educated choice for a place to connect and unwind.

5. Supper

4.6

Exceptional(3212)

$$$$Price: Expensive

• Contemporary American • Downtown

Booked 43 times today

Supper is a cozy restaurant in Downtown San Antonio. Reviewers rave about the 'cozy, restorative vibes', 'warm and fresh aesthetics', and 'unique, inviting and welcoming' ambiance. The restaurant's blend of 'genial South Texas hospitality' and 'American cookery' creates a warm and friendly atmosphere, making it a favorite among locals.

6. Bliss Restaurant

5.0

Exceptional(5050)

$$$$Price: Very Expensive

• Contemporary American • Downtown

Booked 34 times today

Bliss Restaurant is described as 'cozy' and 'quaint' by multiple reviewers. The ambiance is praised as 'thoughtfully crafted', 'intimate', and 'inviting', creating a 'relaxed yet elegant dining experience'. The decor is also highlighted as 'subdued and romantic'. Overall, it's a 'comfortable, eclectic atmosphere' that diners love.

A photo of North Italia - San Antonio restaurant

7. North Italia - San Antonio

4.6

Exceptional(1126)

$$$$Price: Moderate

• Italian • North San Antonio

Booked 45 times today

At North, we set the standard for crave-worthy by serving delicious handmade food daily. Our chefs use only the freshest ingredients to create Italian dishes that consistently satisfy. Enjoy pastas made from scratch daily. Favorites like Bolognese and Chicken Parm. And unexpected bites that go above beyond, like savory Zucca Chips and White Truffle Garlic Bread. Plus an assortment of house-made cocktails, expertly curated wine, and local craft beers that will beckon you to relax, sip and savor every moment you are here.

A photo of Bohanan's Prime Steaks and Seafood restaurant

8. Bohanan's Prime Steaks and Seafood

4.8

Exceptional(8373)

$$$$Price: Very Expensive

• Steakhouse • Downtown

Booked 38 times today

Bohanan's Prime Steaks and Seafood is described as having a 'lovely, relaxing atmosphere' that is 'perfect for drinks, dinner or both'. Customers praised the cozy ambiance and the fact that it's 'one of the few restaurants that provides a quiet, calm dining atmosphere'. The restaurant's 'impeccable service' and 'outstanding food' also contribute to the cozy experience.

A photo of Ocho at Hotel Havana restaurant

9. Ocho at Hotel Havana

4.3

Awesome(471)

$$$$Price: Expensive

• Latin American • Downtown

Booked 18 times today

Situated in a glass conservatory overlooking the River Walk, Ocho serves breakfast, lunch, dinner and late-night snacks indoors and on our breezeway. Ocho has created a menu rooted in the hotel’s pan-Latin cultural influences from Mexico, Cuba and Texas. The cocktail menu highlights the tequila of the hotel’s San Antonio roots with the rum of its Cuban namesake, with a love for old school recipes and, when the occasion calls, the simple satisfaction an ice cold Michelada. Ocho offers complimentary wifi and serves Stumptown espresso drinks to stay or take away.

10. Tenfold Rooftop

4.4

Awesome(133)

$$$$Price: Expensive

• International • Downtown

Booked 43 times today

One of San Antonio’s most distinguished open-air venues, Tenfold Rooftop has garnered quite the buzz as an upcoming luxury, year-round locale—where every statement it makes packs 10x the punch. The bar’s playful cocktail list highlights tequila and mezcal, offering drinks that range from boozy to frozen to refreshing. Embark on a culinary adventure with Tenfold's exclusive '10x Tour'—a prix fixe menu featuring 10 chef-selected dishes from 10 different regions around the world. This curated experience promises to elevate your dining journey, making it 10x better than the rest.

‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you

M
mercedesVIP
San Antonio •9 reviews
5.0
Dined 5 days ago
The food was excellent! The service was fantastic by our waiter Nico. Great experience overall.
More info
Dean's Steak & SeafoodPrice: Very Expensive• Steak• Downtown
•
4.6
A
Angela
San Antonio •15 reviews
5.0
Dined 5 days ago
My sweetheart and I went to a 615 reservation in the food was fantastic! The service was outstanding. Our weight staff person gave excellent service but knew when to let us just enjoy our conversation. The restaurant was not super crowded at that time so I’m not sure the noise level when it is completely full to capacity But we were able to have a lovely conversation and sat by the window. There was no loud music or music at all playing which I really appreciated I can’t stand it when restaurants have this music going and I can’t even talk to my dinner guest or hear them. All in all it was a great experience and I will certainly be there again !
More info
Luce Ristorante E EnotecaPrice: Moderate• Italian• Medical Center
•
4.3
T
TtjeneVIP
San Antonio •13 reviews
5.0
Dined on Mar 5, 2025
Had an excellent experience tonight with the $88 price fixed menu for each person was a wonderful night !
More info
ClementinePrice: Very Expensive• Contemporary American• North Central
•
4.9
MM
MeganM
Greater Boston •4 reviews
5.0
Dined on Mar 1, 2025
I find the patio at Supper to be a great secret! You have views of the river, are in the shade, and can enjoy amazing fresh food. We went for brunch - the avocado toast was beautifully covered with a generous helping of salmon. The deserts were picture worthy and delightful. We will definitely be back for brunch!
More info
SupperPrice: Expensive• Contemporary American• Downtown
•
4.6

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