Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. San Diego

Best Southern American Restaurants in Mission Valley

Price
Regions
Neighborhoods
Top Rated
Dining Options
Seating Options
Award-winning
Accessibility

141 restaurants available nearby

A photo of Gravity Heights Mission Valley restaurant
4.7
Exceptional(211)
Price: Moderate
• Southern american • Mission Valley
Booked 45 times today
Gravity Heights Mission Valley offers an exceptional Californian cuisine experience that perfectly marries the vibrant San Diego beer scene with a stellar dining experience. Located in the heart of Mission Valley, this spacious brewpub is known for its "delicious food, exceptional service, and genuine hospitality." The expansive outdoor beer garden and inviting ambiance make it a perfect spot to enjoy the Californian flavors that diners rave about. Reviews highlight the "amazing place and food," with standout dishes like the "Golden Mustard Chicken wings" and the "Tikka Masala pot pie." It's a must-visit for anyone looking to savor authentic Californian cuisine.
A photo of King's Fish House - Mission Valley restaurant
4.6
Exceptional(2250)
Price: Moderate
• Southern american • Mission Valley
Booked 26 times today
King's Fish House in Mission Valley, San Diego, is a sublime haven for American seafood enthusiasts, proudly offering a "consistently good" experience that diners rave about. This family-run establishment, with its roots deeply embedded in American culinary tradition, is famed for its fresh, daily-changing menu that includes everything from oysters to creatively prepared fish dishes. "Phenomenal service and great food," echo patrons who admire the attentive staff and the inviting atmosphere that caters to both casual gatherings and special occasions. With its irresistible offerings like the "generationally delicious" sourdough bread, King's Fish House is a must-visit for those craving authentic American seafood.
A photo of Great Maple San Diego restaurant
4.8
Exceptional(4409)
Price: Moderate
• Southern american • Hillcrest
Booked 110 times today
Great Maple San Diego, nestled in the vibrant neighborhood of Hillcrest, is a beacon of excellence in Contemporary American cuisine. This modern eatery is celebrated for its "outstanding" food and "exceptional" service, making it a favorite destination for brunch, lunch, and dinner. Diners rave about the delightful maple bacon donuts and "delectable" brisket hash, highlighting the creative use of fresh, local ingredients. Reviewers consistently praise the "huge portions" and "fantastic flavors," ensuring no one leaves hungry. With its inviting atmosphere and "friendly" staff, Great Maple offers a truly authentic and memorable dining experience that captures the essence of Contemporary American cuisine.
A photo of Herb & Wood restaurant
4.6
Exceptional(6499)
Price: Expensive
• Southern american • Little Italy
Booked 92 times today
Herb & Wood in San Diego's vibrant Little Italy is a shining example of exquisite American cuisine. Celebrated Chef Brian Malarkey crafts a menu that elevates rustic, wood-fired dishes, blending Mediterranean flair with California's commitment to seasonality and sustainability. Diners rave about the "incredible dinner" experience, showcasing "amazing, flavorful food" and "outstanding service." The ambiance is described as "beautiful" and "welcoming," making every visit memorable. Signature dishes like the pork belly and filet mignon are praised for their exceptional taste. Whether you're celebrating a special occasion or enjoying a night out, Herb & Wood promises a "truly memorable culinary experience."
A photo of True Food Kitchen - San Diego FV restaurant
4.5
Awesome(1931)
Price: Moderate
• Southern american • Mission Valley
Booked 32 times today
True Food Kitchen in San Diego is a haven for those seeking high-quality Vegetarian and Vegan cuisine. Located in the vibrant Fashion Valley area, this chef-driven restaurant is celebrated for its "delicious and fresh" vegetarian dishes that are both nutrient-dense and full of flavor. Diners rave about standout dishes like the spaghetti squash casserole, which is described as "rich, flavorful, and perfectly seasoned," and the butternut squash pizza, praised for its "unique and delicious take on pizza." With an "inviting atmosphere" and attentive service, True Food Kitchen promises an exceptional dining experience that combines health and indulgence seamlessly.
A photo of Ironside Fish & Oyster restaurant
4.5
Awesome(4571)
Price: Moderate
• Southern american • Little Italy
Booked 115 times today
Ironside Fish & Oyster in San Diego's Little Italy is a quintessential hotspot for authentic American cuisine, seamlessly blending traditional and contemporary flavors. This gem pays homage to its roots in the fishing industry with a mouthwatering menu that features renowned dishes such as the lobster roll and clam chowder, praised for being “chock full of clams.” The vibrant atmosphere and top-notch service are frequently highlighted in reviews, with one diner noting the “excellent experience, food, and ambience.” With a stellar raw bar and an enticing happy hour, Ironside promises a “delightful experience” that diners find irresistible.
A photo of Kettner Exchange restaurant
4.7
Exceptional(1373)
Price: Expensive
• Southern american • Little Italy
Booked 72 times today
Kettner Exchange in Little Italy, San Diego, offers an exceptional Asian fusion experience that is both inventive and authentic. Executive Chef Brian Redzikowski’s creations have earned the restaurant a coveted spot on the Michelin Guide's Bib Gourmand list since 2019, showcasing high-quality meals at accessible prices. Diners rave about the "spicy garlic noodles" and "juicy cheeseburger special," underscoring the delightful fusion of flavors. The rooftop patio with stunning harbor views enhances the dining ambiance, making it perfect for any occasion. Guests frequently praise the "stellar service" and "amazing cocktails," solidifying Kettner Exchange as a must-visit destination for Asian cuisine enthusiasts.
A photo of ARLO San Diego restaurant
4.2
Awesome(771)
Price: Moderate
• Southern american • Mission Valley
Booked 22 times today
ARLO San Diego in Mission Valley is a seafood lover's paradise, offering an authentic and exquisite dining experience. With dishes crafted from fresh, local ingredients, ARLO stands out as a beacon of quality Seafood cuisine. Diners rave about the "tender and packed with flavor" octopus and the "perfectly cooked and seasoned" Pan Roasted Seabass, praising the melt-in-your-mouth quality of the seafood. The restaurant's vibrant atmosphere, coupled with a sweeping patio and inventive cocktails, makes it a must-visit destination. ARLO's accolades, including Best Hotel Restaurant in San Diego Magazine's Best of 2024, further attest to its exceptional seafood offerings.
A photo of Cowboy Star restaurant
4.9
Exceptional(4773)
Price: Very Expensive
• Southern american • Downtown
Booked 74 times today
Cowboy Star in downtown San Diego is a gem of Contemporary American cuisine, capturing the essence of regional American heirloom recipes with a modern twist. Their commitment to using locally sourced, natural, and organic ingredients shines through every dish, offering "exceptional quality" that diners rave about. Known for their impeccable service and warm atmosphere, Cowboy Star is celebrated for its perfectly cooked steaks, with one reviewer exclaiming, "the best steakhouse in San Diego, PERIOD." The diverse menu, which includes top-notch wine and cocktails, ensures that every visit is a "memorable and enjoyable experience," making Cowboy Star a must-visit for any steak lover.
A photo of Blanco Cocina + Cantina – Fashion Valley restaurant
4.7
Exceptional(561)
Price: Moderate
• Southern american • Mission Valley
Booked 17 times today
Blanco Cocina + Cantina – Fashion Valley is a standout destination in Mission Valley, San Diego for those seeking an exceptional cocktail bar experience. Known for its vibrant atmosphere and refreshing drinks, Blanco’s cocktail bar is a "perfect spot for sipping margaritas," as delighted patrons often rave. The spicy skinny margaritas are a particular highlight, earning consistent praise for their bold flavors and delightful presentation. With an inviting outdoor area featuring comfortable seating and heat lamps, it’s an ideal place to unwind. Whether you're enjoying a casual hangout or celebrating a special occasion, Blanco ensures your cocktail experience is nothing short of extraordinary.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.
  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable, Inc. 1 Montgomery St Ste 500, San Francisco CA 94104 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo