Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. San Francisco Bay Area

Best Southern American Restaurants in Mission Bay / South Beach

Price
Regions
Neighborhoods
Top Rated
Dining Options
Seating Options
Award-winning
Accessibility

144 restaurants available nearby

A photo of House of Prime Rib restaurant
1. House of Prime Rib
4.8
Exceptional(15842)
Price: Very Expensive
• Southern american • Civic Center / Hayes Valley / Van Ness
Booked 249 times today
House of Prime Rib, nestled in the vibrant Civic Center / Hayes Valley / Van Ness neighborhood of San Francisco, is a bastion of exceptional American cuisine, specializing in an unparalleled prime rib experience. Celebrated for its 62-year legacy, this restaurant is a favorite for its "juicy and perfectly cooked" prime rib selections, from the English Cut to the King Henry Cut. Patrons rave about the "tender and flavorful" meat and the classic accompaniments like creamed spinach and Yorkshire pudding, emphasizing that it's not just a meal but an "unforgettable experience." The ambiance, described as energetic and celebratory, perfectly complements the top-notch service and old-school charm, making House of Prime Rib a must-visit for anyone seeking the quintessential American dining experience.
A photo of The Palm Court at RH San Francisco restaurant
2. The Palm Court at RH San Francisco
4.8
Exceptional(1780)
Price: Very Expensive
• Southern american • Potrero Hill / Dogpatch
Booked 108 times today
The Palm Court is located in RH San Francisco's Gallery at the Historic Bethlehem Steel Building. Recalling the distinctive glamour of San Francisco's Gilded Age, the stunning statement space is sheathed in Italian Calacatta gold marble and features a cascading center fountain, towering Medjool date palms and glimmering chandeliers. Adjacent to the restaurant, two luminous wine bars offer exceptional wines and Champagnes from around the world.For group dining inquiries, please email: sfhospitality@rh.com
A photo of Miller & Lux restaurant
3. Miller & Lux
4.7
Exceptional(1173)
Price: Very Expensive
• Southern american • Mission Bay / South Beach
Booked 20 times today
Nestled in the vibrant Mission Bay/South Beach neighborhood of San Francisco, Miller & Lux redefines the Contemporary American dining experience. Spearheaded by the renowned Tyler Florence, this modern American Steakhouse delivers an unmatched culinary delight. From the highest-quality steaks sourced from America's finest ranches to a fresh, sustainable seafood selection, each dish is a testament to Tyler's innovative approach to classic American luxury. Patrons rave about the "impeccable service" and "culinary masterpieces," with special mentions of the unique tableside Caesar salad and the meticulously curated wine list. Whether you're there for a "splurge dinner" or celebrating a special occasion, Miller & Lux promises an "outstanding" gastronomic journey that perfectly captures the essence of refined American cuisine.
A photo of The Rotunda at Neiman Marcus - San Francisco restaurant
4. The Rotunda at Neiman Marcus - San Francisco
4.8
Exceptional(6103)
Price: Expensive
• Southern american • Downtown / Union Square
Booked 68 times today
The Rotunda at Neiman Marcus in San Francisco's Union Square is a quintessential destination for those seeking an exceptional American dining experience. Known for its elegant ambiance and meticulous service, The Rotunda offers a luxurious afternoon tea service that has won the hearts of locals and tourists alike. Patrons rave about the "delicious assortment of food" and "excellent ambience," highlighting the restaurant's ability to deliver a top-tier culinary experience. From the superb seafood selections like the praised shrimp and crab Louie salad to the classic American burger, every dish is crafted with excellence. Guests continually commend the Rotunda for its "outstanding service" and "beautiful setting," making it a must-visit for anyone looking to indulge in the finest American cuisine in a stunning, historic venue.
A photo of Wayfare Tavern restaurant
5. Wayfare Tavern
4.6
Exceptional(7831)
Price: Moderate
• Southern american • Financial District / Embarcadero
Booked 64 times today
At the heart of San Francisco's bustling Financial District, Wayfare Tavern stands as a beacon of American cuisine, offering a nostalgic yet refined dining experience. Chef Tyler Florence masterfully crafts a menu that captures the essence of early 20th century American fare, earning accolades from diners who rave about the "outstanding" food and service. Known for its moist and flavorful fried chicken and rustic yet elegant setting reminiscent of a Victorian parlor, Wayfare Tavern delivers a unique blend of tradition and innovation. Patrons consistently praise the "perfectly cooked" dishes and the tavern's ability to turn a meal into a cherished memory, making it a cornerstone of the San Francisco dining scene.
A photo of Shelby's Rooftop restaurant
6. Shelby's Rooftop
4.5
Awesome(311)
Price: Very Expensive
• Southern american • SOMA
Booked 56 times today
Shelby's Rooftop in the heart of SOMA, San Francisco, epitomizes the quintessential rooftop bar experience with its expertly-crafted cocktails and chic ambiance. Guests rave about the "spectacular views" and the vibrant, "mellow and classy" atmosphere, making it a standout for those seeking a premium bar, lounge, or bottle service venue. Patrons consistently highlight the "delicious" drinks and "great vibes," with special mentions of the mezcal cocktails being "absolutely super savory." The service at Shelby's is commended for being welcoming and attentive, ensuring a memorable visit. Whether you're celebrating a special occasion or just enjoying a casual night out, Shelby's Rooftop offers a breathtaking setting with "top-notch service" and an unmatched urban backdrop, making it a must-visit destination in San Francisco.
A photo of Tartine Manufactory - San Francisco restaurant
7. Tartine Manufactory - San Francisco
4.6
Exceptional(1029)
Price: Expensive
• Southern american • Mission District
Booked 30 times today
Tartine Manufactory in San Francisco's vibrant Mission District is hailed as a haven for pizza aficionados, offering a delightful culinary experience with its world-class sourdough pizzas. Renowned for its market-driven menu that showcases the artisanal bread-making prowess of Chad Robertson, the restaurant earns rave reviews for its unique offerings. Guests consistently praise the "delicious" and "creative" pizza options, like the seasonal corn pizza which has been described as "spectacular." The inviting atmosphere complements the exceptional food, with one review noting, "The service, environment, and food were incredible." Whether it's the cacio e pepe pizza enhanced with fresh arugula or the burrata peach salad, each dish is crafted with the utmost care, making Tartine Manufactory a must-visit for those seeking authentic and high-quality Pizzeria cuisine in San Francisco.
A photo of State Bird Provisions restaurant
8. State Bird Provisions
4.7
Exceptional(3242)
Price: Very Expensive
• Southern american • Western Addition
Booked 61 times today
State Bird Provisions in San Francisco's Western Addition neighborhood offers a truly American dining experience that captures both the spirit and innovation of contemporary American cuisine. Renowned for its unique approach, the restaurant features a dim sum-style service that delivers a parade of creative and seasonal dishes, earning high praise from diners. Guests rave about the "extraordinary place with extraordinarily good food" and the "interesting, seasonal, and well-balanced flavors." The energy and creativity of the menu make every visit a delightful adventure, with standouts like the duck liver mousse and the smoked trout dip. The combination of top-notch service and a lively atmosphere ensures a memorable dining experience that epitomizes the best of American culinary excellence. This gem is a proud testament to the rich, evolving food scene of San Francisco.
A photo of Boulevard restaurant
9. Boulevard
4.7
Exceptional(9099)
Price: Very Expensive
• Southern american • Financial District / Embarcadero
Booked 29 times today
Boulevard, nestled in the vibrant Financial District/Embarcadero area of San Francisco, epitomizes the essence of Contemporary American cuisine with an innovative twist. The restaurant recently refreshed its approach, offering a multi-course prefix menu that dazzles diners. Reviewers rave about its culinary delights, describing dishes like the "out of this world" strawberry yuzu sundae and flavor-packed stuffed morels as highlights of their dining experience. Boulevard's commitment to quality is evident, with one patron noting, "Boulevard never disappoints! Excellent food. We have eaten there many times and it is always exceptional." This gem provides not just a meal but a memorable dining adventure, making it a must-visit for those seeking exceptional Contemporary American fare in a sophisticated setting.
A photo of Historic John's Grill restaurant
10. Historic John's Grill
4.7
Exceptional(7405)
Price: Expensive
• Southern american • Downtown / Union Square
Booked 85 times today
Nestled in the heart of Downtown San Francisco near Union Square, Historic John's Grill offers an exquisite seafood dining experience that has delighted guests since 1908. Known for its "expertly prepared fresh seafood," this landmark establishment is a favorite among celebrities and locals alike. Diners rave about the "amazing" lobster bisque and the "delicious" broiled halibut, highlighting the freshness and quality of the dishes. With its vibrant atmosphere and a nod to classic San Francisco charm, John's Grill continues to be a top choice for seafood lovers. As one patron put it, "Dinner was outstanding!! I had the broiled halibut which was so fresh and my husband had the Ribeye (also delicious). Our server Daniel was excellent! We will be back!!" Whether you're a local or just visiting, a meal at John's Grill is a must for anyone seeking the best seafood in the city.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you
From verified diners like you

Explore OpenTable

Discover
OpenTable
  • About Us
  • Blog
  • Careers
  • Press
More
Our sites
Businesses
  • Delight more diners
Join us on
  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable, Inc. 1 Montgomery St Ste 500, San Francisco CA 94104 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo