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Best Southern American Restaurants in W. University / Med Center

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159 restaurants available nearby

A photo of Drake's Hollywood - Houston restaurant
4.6
Exceptional(173)
Price: Very Expensive
• Southern american • Montrose
Booked 85 times today
Drake's Hollywood in Montrose, Houston, is a haven for steak aficionados, offering an experience that is as authentic as it is exceptional. Known for its “amazing” dry-aged Delmonico steaks, the restaurant consistently receives rave reviews for both its culinary offerings and vibrant ambiance. Diners frequently highlight the “mouth-watering” quality of the steaks, with one reviewer declaring it as “the best steak” they've ever tasted. Each steak is perfectly prepared, capturing the essence of Old Hollywood glamour with every bite. The impeccable service and lively atmosphere only enhance the dining experience, making it a must-visit destination for steak lovers.
A photo of Milton's restaurant
4.7
Exceptional(79)
Price: Expensive
• Southern american • Rice Village
Booked 73 times today
Milton's is a delightful culinary gem nestled in the heart of Rice Village, Houston, offering an exceptional blend of American and Italian-American cuisine that truly stands out. Known for "delicious food and perfect service," Milton's is celebrated for its homemade pastas, like the unforgettable mushroom pasta, and wood-fired meats that offer a comforting yet innovative dining experience. Guests rave about the "outstanding service and food quality," making it a must-visit for those seeking authentic American flavors with a twist. The vibrant atmosphere and impeccable service ensure that every visit is memorable, promising patrons a taste of true American dining excellence.
A photo of Rosie Cannonball restaurant
4.7
Exceptional(42)
Price: Expensive
• Southern american • Montrose
Booked 72 times today
Rosie Cannonball in Montrose, Houston, is a vibrant celebration of authentic Italian cuisine, skillfully prepared with a focus on live fire cooking. The restaurant's wood-burning oven and grill bring out the best in their hand-crafted pastas and wood-fired pizzas, drawing rave reviews for their "perfection" and "top quality." The menu, inspired by fresh, local ingredients, pairs exquisitely with an Italian-centric wine list curated by Master Sommelier June Rodil. Diners consistently praise the "extraordinary" service and "exceptional" food, making it a beloved gem in the heart of Houston. With its lively atmosphere and delectable offerings, Rosie Cannonball promises an unforgettable Italian dining experience.
A photo of Eunice restaurant
4.7
Exceptional(2617)
Price: Moderate
• Southern american • Upper Kirby / Shepherd Corridor
Booked 24 times today
Eunice, nestled in the vibrant Upper Kirby area of Houston, is a seafood lover's paradise, offering a tantalizing menu inspired by the rich flavors of South Louisiana. The restaurant's seafood dishes, such as the "best gumbo I ever had" and the "outstanding oysters," are frequently praised for their authenticity and quality, transporting diners straight to the Gulf Coast. Executive Chef Drake Leonards masterfully infuses European influences with local ingredients, creating a unique culinary experience that keeps guests coming back for more. The warm, inviting atmosphere and exceptional service make Eunice an unforgettable dining destination for seafood enthusiasts.
A photo of Balboa Surf Club restaurant
4.8
Exceptional(59)
Price: Expensive
• Southern american • Galleria / Uptown
Booked 51 times today
Balboa Surf Club in the vibrant Uptown Houston area is a must-visit for seafood lovers. The restaurant is renowned for its exquisitely fresh seafood, with diners raving about the "best seafood I've ever had in Houston!" Guests are consistently impressed by the quality and creativity of the offerings, like the "mind-blowing creative" sushi rolls and the "HUGE crab cake" packed with flavor. The Miso Salmon is frequently highlighted as "some of the best tasting salmon," while the King Crab hand roll is hailed as "the best bite in Houston." Balboa Surf Club promises a culinary experience where freshness and authenticity shine through every dish.
A photo of Clark's Oyster Bar - Houston restaurant
4.8
Exceptional(409)
Price: Expensive
• Southern american • Montrose
Booked 51 times today
Clark's Oyster Bar in Montrose, Houston, is a shining gem of Contemporary American cuisine, delighting diners with its exquisite blend of fresh seafood and classic American dishes. This vibrant restaurant is renowned for its "amazing oysters and seafood," bringing flavors from places like Maine and the Pacific Northwest to the heart of Houston. Diners rave about the "delicious variety of oysters" and the "best cioppino ever," making it a must-visit for seafood aficionados. The light, airy ambiance, complete with a charming outdoor patio, offers a perfect setting to enjoy a "wonderful experience" with "great food and service." Whether you're savoring a classic lobster roll or indulging in a luscious key lime tart, Clark's promises an authentic and memorable Contemporary American dining experience.
A photo of Leo's River Oaks restaurant
4.6
Exceptional(87)
Price: Very Expensive
• Southern american • River Oaks
Booked 50 times today
Leo's River Oaks in Houston is a shining star of Contemporary American cuisine, offering an exquisite dining experience that's hard to match. Guests rave about the "amazing food and cocktails," with standout dishes like the King Salmon and deviled egg trio leaving a lasting impression. The restaurant's elegant decor and live piano music provide a sophisticated atmosphere, perfect for special occasions or a memorable night out. Diners frequently mention the "outstanding service," highlighting the attentive and knowledgeable staff who enhance the dining experience. Leo's River Oaks is truly a "must-try" for anyone seeking exceptional Contemporary American dining in River Oaks.
A photo of Hudson House - River Oaks restaurant
4.7
Exceptional(412)
Price: Moderate
• Southern american • River Oaks
Booked 84 times today
Hudson House - River Oaks is a seafood lover's paradise, bringing the authentic flavors of the East Coast to Houston with a flair for freshness and quality. The oysters, "flown in daily," are a testament to their commitment to providing only the best, and pair perfectly with their renowned "World’s Coldest Martinis." The reviews speak volumes, with diners raving about the "superb" raw oysters and the "best grilled redfish" they've ever had in Houston. The restaurant’s dedication to serving consistently delicious seafood makes it a standout choice for anyone craving an unforgettable seafood dining experience.
A photo of JOEY Uptown restaurant
4.6
Exceptional(97)
Price: Moderate
• Southern american • Westside
Booked 130 times today
JOEY Uptown in Westside, Houston, offers an exceptional dining experience with its Global, International cuisine. With a team of celebrated Executive Chefs, this restaurant delivers a "scrumptious" and "perfectly crafted" menu that has patrons raving about its diverse and flavorful dishes. The open concept dining room and temperature-controlled patio create a lively and inviting atmosphere, accented by art from local talents. Guests consistently praise the "fantastic food, excellent service, and great vibe," making JOEY Uptown a must-visit for anyone seeking a unique and memorable culinary adventure. Whether for a special occasion or a casual night out, this spot is sure to impress.
A photo of Grace's restaurant
4.8
Exceptional(4311)
Price: Expensive
• Southern american • Upper Kirby / Shepherd Corridor
Booked 51 times today
Grace's, nestled in the vibrant Upper Kirby / Shepherd Corridor of Houston, offers an authentic Comfort Food experience that transports diners back to the heartwarming meals of their childhood. Inspired by Johnny Carrabba’s grandmother, Grace Mandola, the restaurant serves up exceptional dishes filled with "the best home style cooking in Houston." Guests frequently rave about iconic comfort dishes, like the "possibly the best chicken fried chicken I've ever eaten," paired with creamy mashed potatoes and jalapeño cream gravy. The charming atmosphere, coupled with outstanding service, creates a cozy haven for diners seeking both nostalgia and culinary excellence.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you
From verified diners like you
  • Weiwei
    Houston •3 reviews
    5.0
    Dined today
    Very friendly staff. Delicious food and creative drinks. Very much enjoyed our group dinner there.
    More info
    Lucille'sPrice: Expensive• Southern• Museum District
    4.5
  • Jaliyah
    Houston •1 review
    5.0
    Dined 1 day ago
    My sister and I had dinner at Grace’s, and it was such a great experience! We started with the Fried Green Tomatoes, which were so crispy and flavorful—a great way to kick off the meal. And we were complimentary cornbread with a sweet butter (delicious by the way). For my main dish, I had the Cajun Stuffed Chicken, and it was amazing. I upgraded to the Crawfish Mac and Cheese (so worth it!) and swapped the collard greens for seasoned green beans. Shoutout to our server, who was super helpful and suggested those upgrades—she really made the meal extra special. The vibe at Grace’s is warm and cozy, like being at your grandmother’s house. The dress is casual, but going business casual would feel fitting for this location—it has that polished yet inviting atmosphere. The only small downside was that the table next to us was a bit loud, but honestly, it didn’t take away from how much we enjoyed everything else. My sister and I both left happy and full, and we’ll definitely be back!
    More info
    Grace'sPrice: Expensive• American• Upper Kirby / Shepherd Corridor
    4.8
  • Sheila
    Austin •2 reviews
    5.0
    Dined on Dec 23, 2024
    I have eaten here several times and enjoyed both the food and the experience. It was a bit congested today, particularly as we were seated very close to where counter seats were located. The food I ordered required a substitute due to something not being available, which was a disappointment, but additional shrimp was offered and accepted as a substitute. The waitress was very competent and friendly. Valet service was timely and professional as previously experienced.
    More info
    Ouisie's TablePrice: Moderate• American• Galleria / Uptown
    4.8
  • EugeniaVIP
    Houston •17 reviews
    5.0
    Dined on Dec 22, 2024
    Amazing food and service and beautiful environment The Manager at Tribute in the Houstonian is an amazing person and can help you celebrate amazing bdays there. I truly recommend them for family environment, great food, healthy options and beautiful place!
    More info
    TRIBUTEPrice: Expensive• Southern• Westside
    4.9
  • Jillian
    Houston •1 review
    5.0
    Dined on Dec 22, 2024
    Went to celebrate several birthdays. Making the reservation was easy. Seating was available upon arrival. Service was great. Jared was our waiter. He was friendly, professional, and knowledgeable of the menu. Would recommend anf plan on returning.
    More info
    Kulture RestaurantPrice: Expensive• Southern• Downtown
    4.5
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