Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. San Diego

Best American Restaurants in Little Italy

Price
Regions
Neighborhoods
Top Rated
Dining Options
Seating Options
Award-winning
Accessibility

128 restaurants available nearby

A photo of Ironside Fish & Oyster restaurant
4.4
Awesome(4534)
Price: Moderate
• American • Little Italy
Booked 81 times today
Nestled in the heart of San Diego's vibrant Little Italy, Ironside Fish & Oyster is a gem for seafood enthusiasts. Celebrated for its dedication to the freshest and highest quality seafood, this restaurant has transformed a historic auction house into a bustling seafood haven with an expansive raw bar and open-air culinary hubs. Patrons rave about their "10/10 plump oysters" and assert that the "fish and chips may be the best in San Diego." Not to be missed are their lobster rolls, described as "the best thing I ever had!" With its cool vibe and exceptional service, Ironside Fish & Oyster offers an unforgettable dining experience right by the docks where the city's fishing legacy continues to thrive.
A photo of Herb & Wood restaurant
4.7
Exceptional(6438)
Price: Expensive
• American • Little Italy
Booked 59 times today
Herb & Wood in Little Italy, San Diego, epitomizes the essence of Mediterranean cuisine with a delightful twist of Californian flair. Celebrated Chef Brian Malarkey crafts a menu that transforms simple ingredients into a symphony of flavors, all centered around a wood-fired concept that accentuates each dish's rustic, authentic taste. Reviewers consistently praise the restaurant's vibrant atmosphere and innovative dishes, with one guest exclaiming, "The bone marrow and oyster dish was especially impressive!" and another noting the "swordfish was very fresh and tasty." Herb & Wood not only offers a feast for the taste buds but also a Mediterranean dining experience that is both heartfelt and memorable, making it a culinary jewel in San Diego.
A photo of Kettner Exchange restaurant
4.7
Exceptional(1334)
Price: Expensive
• American • Little Italy
Booked 44 times today
Kettner Exchange in Little Italy, San Diego, is a paragon of Contemporary American cuisine, offering a unique dining experience that reflects the very essence of culinary innovation. With its expansive harbor views from the rooftop patio and the culinary prowess of Executive Chef Brian Redzikowski, the restaurant has consistently wowed diners and critics alike, earning a spot on the Michelin Guide's Bib Gourmand list since 2019. Reviews often highlight the inspired menu, such as one diner’s praise for the “magical” way flavors and textures are combined. Another reviewer raves, “UNBELIEVABLE! THE MOST INCREDIBLE DINING EXPERIENCE OF MY LIFE,” underscoring the exceptional quality and creativity on display. Kettner Exchange's commitment to a thrilling gastronomic journey makes it a must-visit for those seeking the best in Contemporary American fare.
A photo of Coco Maya restaurant
4.7
Exceptional(375)
Price: Expensive
• American • Little Italy
Booked 4 times today
Coco Maya in Little Italy, San Diego, is a delightful revelation in Contemporary American cuisine, offering a creative twist on classic American fare. The restaurant's use of a traditional Spanish-style coal-fired Josper oven brings a unique flavor profile to robust, flavorful proteins, setting it apart in a neighborhood rich with culinary offerings. Reviewers rave about the diverse menu, highlighting dishes like the "delicious" short rib pasta and "amazing" skirt steak. The ambiance, enhanced by sweeping views of Little Italy and a vibrant rooftop setting, is consistently praised. It’s not just the food that receives acclaim; the cocktail program, featuring a diverse mezcal and tequila selection, is also a highlight. Visitors describe their dining experience as “unforgettable,” noting the "fun atmosphere" and exceptional service that make Coco Maya a must-visit spot in San Diego.
A photo of Petrini's restaurant
4.5
Awesome(424)
Price: Moderate
• American • Little Italy
Booked 10 times today
Petrini's in San Diego's vibrant Little Italy is a culinary gem, celebrated for its exceptional American cuisine with a unique twist. This eatery stands out for its dedication to quality and authenticity, drawing diners back time and again. Guests rave about the "delicious and homemade tasting" dishes, highlighting the smoked salmon alfredo and the innovative diablo shrimp as must-tries. The restaurant's atmosphere is consistently praised, with one visitor noting it as a "quiet, quaint, and beautiful eatery with old world recipes." Petrini's commitment to excellence is evident in every dish, making it a top destination for those seeking authentic American flavors in San Diego.
A photo of CUCINA urbana restaurant
4.7
Exceptional(7084)
Price: Moderate
• American • Banker's Hill
Booked 46 times today
Nestled in the vibrant Bankers Hill neighborhood of San Diego, CUCINA urbana offers a sublime blend of American cuisine with a unique twist. This gem has been delighting patrons since 2009, merging a cozy farmhouse vibe with a modern art installation, making each dining experience both comforting and visually stimulating. The restaurant's dedication to quality is evident, with diners raving about the "stellar" food and "exceptional" service. Highlights include the meatballs with a "spicy" kick and the perfectly cooked rigatoni, not to mention the "spectacular" desserts like tiramisu and limoncello mousse tart. The innovative wine program allows guests to select from a range of both familiar and rare vintages at retail prices, enhancing meals or to enjoy at home. CUCINA urbana isn't just a meal; it's a culinary celebration in the heart of San Diego.
A photo of Cowboy Star restaurant
4.9
Exceptional(4725)
Price: Very Expensive
• American • Downtown
Booked 46 times today
Cowboy Star in the vibrant heart of Downtown San Diego epitomizes the essence of Contemporary American cuisine with a wild-west twist. Celebrated for its dedication to regional heirloom recipes and superior service, Cowboy Star stands out for its use of local, natural, and organic ingredients, ensuring every dish sings with authenticity and freshness. The menu showcases exceptional dishes, such as the Niman Ranch all-natural beef, earning it rave reviews for the "best steak in SD" and a culinary experience that is both genuine and heartwarming. Diners consistently praise the "excellent vibe" and "impeccable service," making it a must-visit for anyone seeking the pinnacle of Contemporary American dining in San Diego.
A photo of Books + Records restaurant
4.7
Exceptional(367)
Price: Expensive
• American • Banker's Hill
Booked 16 times today
Books + Records in Banker's Hill, San Diego, is not just a place to dine; it's an experience of culinary and mixological artistry. Renowned for its craft cocktails, this spot stands out with creations like the "Purple Rain," a unique blend of Japanese whisky that captures the essence of the restaurant's innovative approach to drinks. Praised for its vibrant atmosphere and live music that complements every sip, Books + Records has been featured on Eater's Heat Map and listed among San Diego's Hottest Cocktail Bars. Guests continuously rave about the quality, with one noting, "The cocktails were delish," underscoring the establishment's commitment to excellence in every glass. Whether you're in for the live jazz or the acclaimed "old-fashioned," Books + Records delivers an unforgettable cocktail bar experience.
A photo of Parc Bistro-Brasserie restaurant
4.8
Exceptional(3086)
Price: Moderate
• American • Banker's Hill
Booked 26 times today
Parc Bistro-Brasserie, nestled in the heart of Bankers Hill, San Diego, is a celebrated haven of French cuisine, meriting its spot on OpenTable’s “100 Best Neighborhood Gems in America for 2021.” Renowned for its seafood-focused approach, the bistro expertly balances classic French dishes with global inspirations. Patrons rave about the "outstanding jumbo shrimp cocktail & steak frites" and the brunch that has been crowned as the "Best Brunch in San Diego." The allure of Parc Bistro-Brasserie is enhanced by its "exceptional food" and ambiance that transforms a meal into a "Paris escape." With glowing reviews like "By far my favorite French restaurant in San Diego! The food is superb!", it's clear that Parc Bistro-Brasserie is a culinary gem that continuously captivates both locals and visitors alike.
A photo of Water Grill - San Diego restaurant
4.7
Exceptional(3582)
Price: Expensive
• American • Downtown
Booked 42 times today
Nestled in the vibrant heart of San Diego's Gaslamp District, Water Grill San Diego offers an unparalleled seafood experience that has consistently earned it top ratings among the city’s seafood dining spots. Right from the bustling docks, their boat-to-table strategy ensures only the freshest seafood, including an impressive variety of fish, lobsters, crabs, and oysters, makes it to your plate, often within hours of being caught. Patrons rave about their 'exceptional' seafood dishes, with the Chilean seabass and lobster frequently highlighted as 'possibly the best ever had.' Each dish is crafted to showcase the natural flavors of the high-quality ingredients, earning glowing reviews for both the culinary finesse and the lively, elegant ambiance. Whether it's the 'amazing' oyster sampler or the expertly prepared sea bass, Water Grill promises a memorable dining adventure right in the bustling center of San Diego.

How is content generated

See what locals rave about

From verified diners like you
From verified diners like you
  • Vincentvip
    Washington, D.C. Area •71 reviews
    5.0
    Dined 3 days ago
    Incredible! We started with the sushi-grade Hot Oil Seated Salmon and the Whipped Buttermilk Ricotta with charred bread for dipping. We also had the Roasted Chinese Eggplant sitting on lemon yogurt and pine nuts that had the appearance of sushi and the taste of beautifully seasoned eggplant. We also had the juicy cheeseburger special which had perfect fries.
    More info
    Kettner ExchangePrice: Expensive• Contemporary American• Little Italy
    4.7
  • JoAnnvip
    San Diego •4 reviews
    5.0
    Dined 4 days ago
    Unmatched hospitality! The server was knowledgeable about the food and able to describe them well. We didn’t have great luck with the clams, they were very chewy & overcooked but the broth was delicious. They took it back and a sweet manager, (I’m forgetting names) sent a hamachi that was to die for! Everything else that hit the table was delicious and we were very impressed. The bubbly and celebration desert was super appreciated as well. Honestly made my birthday dinner feel extra special, some places really don’t go the extra mile but they sure know how to impress.
    More info
    Herb & WoodPrice: Expensive• Californian• Little Italy
    4.7
  • Anabel
    San Diego •1 review
    5.0
    Dined on Nov 21, 2024
    There was a heating lamp above us that kept me cozy. We had a great time.
    More info
    Coco MayaPrice: Expensive• Contemporary American• Little Italy
    4.7
  • Nataliavip
    San Diego •21 reviews
    5.0
    Dined on Nov 19, 2024
    What can I say? This is easily one of the best happy hour spots in San Diego! The ambiance is stunning, the service is outstanding, and the food is absolutely incredible. We had yet another fantastic experience here, this time for an early dinner to celebrate my kid’s birthday. The oysters were incredibly fresh, the Japanese sweet potatoes are a must-try, the fish and chips were amazing—so fresh and moist—and the clam chowder was perfection. The smoked trout dip wasn’t my favorite this time, but it was still a solid appetizer. Our server, Mike, was exceptional—attentive, polite, and spot-on with his food recommendations. We’ll definitely be back, and if you’ve never been to this place, make a reservation now. You can thank me later!
    More info
    Ironside Fish & OysterPrice: Moderate• Seafood• Little Italy
    4.4
  • Gigivip
    Las Vegas •67 reviews
    5.0
    Dined on Nov 13, 2024
    Love this place. The be e food is great and we’re going back again this same trip.
    More info
    Petrini'sPrice: Moderate• Italian• Little Italy
    4.5

Discover best American restaurants in Little Italy

Discover the vibrant American dining scene in San Diego's Little Italy, where the blend of cultural heritage and culinary innovation creates a memorable gastronomic experience. This bustling neighborhood is home to an array of restaurants that masterfully serve American cuisine with a unique twist, emphasizing local ingredients, sustainable practices, and creative flair. Each establishment prides itself on delivering not only high-quality food but also an ambiance that complements the culinary delights, making every meal a special occasion. Whether you're in the mood for rustic, wood-fired dishes that showcase the Californian ethos of seasonality, or classic American seafood prepared with a contemporary edge, Little Italy has something to tantalize every palate. The area is particularly noted for its excellent service and the ability to maintain a high standard of dining experience that keeps locals and tourists alike coming back for more. From award-winning breweries to farm-to-table eateries, the emphasis on fresh, top-notch ingredients is evident in every dish served. San Diego's Little Italy is not just about food; it's about an experience that combines great cuisine with vibrant street life and picturesque settings. Whether you're planning a casual lunch, a business meeting, or a special celebration, Little Italy's American dining venues promise a feast not just for your taste buds but for all your senses.

  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable, Inc. 1 Montgomery St Ste 500, San Francisco CA 94104 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo